Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128222
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128222
Synonyms:
(4-bromanyl-1-methyl-pyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-1-methyl-3-pyrazolyl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-1-methyl-pyrazol-3-yl)-indolin-1-yl-methanone | (4-bromo-1-methylpyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | 1-[(4-bromo-1-methyl-1H-pyrazol-3-yl)carbonyl]indoline | MLS000703851 | SMR000227233 | cid_903405
Type:
Small organic molecule
Emp. Form.:
C13H12BrN3O
Mol. Mass.:
306.158
SMILES:
Cn1cc(Br)c(n1)C(=O)N1CCc2ccccc12
Structure:
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