Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM55866
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM55866
Synonyms:
1-Cyclopropyl-3-{2-[2-(1,3-dimethyl-2,4,6-trioxo-tetrahydro-pyrimidin-5-ylidenemethyl)-1H-indol-3-yl]-eth yl}-thiourea | 1-cyclopropyl-3-[2-[2-[(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]-1H-indol-3-yl]ethyl]thiourea | 1-cyclopropyl-3-[2-[2-[(2,4,6-triketo-1,3-dimethyl-hexahydropyrimidin-5-ylidene)methyl]-1H-indol-3-yl]ethyl]thiourea | 1-cyclopropyl-3-[2-[2-[[1,3-dimethyl-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]methyl]-1H-indol-3-yl]ethyl]thiourea | MLS000332961 | SMR000436309 | cid_5620224
Type:
Small organic molecule
Emp. Form.:
C21H23N5O3S
Mol. Mass.:
425.504
SMILES:
CN1C(=O)N(C)C(=O)C(=Cc2[nH]c3ccccc3c2CCNC(=S)NC2CC2)C1=O |(14.98,-2.98,;13.64,-3.75,;13.64,-5.29,;14.98,-6.06,;12.31,-6.06,;12.31,-7.6,;10.98,-5.29,;9.64,-6.06,;10.98,-3.75,;9.64,-2.98,;8.1,-2.98,;7.2,-4.22,;5.75,-3.75,;4.41,-4.52,;3.08,-3.75,;3.08,-2.21,;4.41,-1.44,;5.75,-2.21,;7.2,-1.74,;7.68,-.27,;6.65,.87,;7.13,2.34,;6.1,3.48,;4.6,3.16,;6.58,4.94,;5.55,6.09,;5.24,7.6,;4.09,6.57,;12.31,-2.98,;12.31,-1.44,)|
Structure:
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