Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128234
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128234
Synonyms:
(5-bromopyrimidin-2-yl)-[(E)-1-(3-nitrophenyl)ethylideneamino]amine | 5-bromanyl-N-[(E)-1-(3-nitrophenyl)ethylideneamino]pyrimidin-2-amine | 5-bromo-N-[(E)-1-(3-nitrophenyl)ethylideneamino]-2-pyrimidinamine | 5-bromo-N-[(E)-1-(3-nitrophenyl)ethylideneamino]pyrimidin-2-amine | MLS001211234 | N-(5-Bromo-pyrimidin-2-yl)-N'-[1-(3-nitro-phenyl)-ethylidene]-hydrazine | SMR000513413 | cid_5338790
Type:
Small organic molecule
Emp. Form.:
C12H10BrN5O2
Mol. Mass.:
336.144
SMILES:
C\C(=N/Nc1ncc(Br)cn1)c1cccc(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: