Reaction Details Report a problem with these data
Target
Solute carrier organic anion transporter family member 2A1
Ligand
BDBM144795
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
298.15±n/a K
IC50
609±n/a nM
Comments
extracted
Citation
 Schuster, VL; Chi, Y; Wasmuth, AS; Pottorf, RS; Olson, GL Prostaglandin transporter inhibitors and uses thereof US Patent  US8952150 Publication Date 2/10/2015 
Target
Name:
Solute carrier organic anion transporter family member 2A1
Synonyms:
Matr1 | Matrin F/G 1 | Prostaglandin transporter (PGT) | SO2A1_RAT | Slc21a2 | Slco2a1 | Solute carrier family 21 member 2
Type:
Protein
Mol. Mass.:
70404.97
Organism:
Rattus norvegicus (Rat)
Description:
Q00910
Residue:
644
Sequence:
MGLLLKPGARQGSGTSSVPDRRCPRSVFSNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHFGALPPSKCHSTVPDTHKETSSLWGLMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVTAEETMQTEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVPLFFMGCSTSAVAEVYPPSTSSSIHPQQPPACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKEPIYLNCSCVSGGSASAKTGSCPTSCAQLLLPSIFLISFAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCSGRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNREYSLQENTSGLI
  
Inhibitor
Name:
BDBM144795
Synonyms:
US8952150, 22 | US8952150, 83
Type:
Small organic molecule
Emp. Form.:
C36H38N8O5
Mol. Mass.:
662.7375
SMILES:
Oc1ccc(Nc2nc(NCCOCCOCCNC(=O)c3ccccc3)nc(Nc3ccc(cc3)C(=O)NCc3ccccc3)n2)cc1
Structure:
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