Reaction Details Report a problem with these data
Target
Lymphokine-activated killer T-cell-originated protein kinase
Ligand
BDBM149044
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.97±n/a nM
Comments
extracted
Citation
 Nakamura, Y; Matsuo, Y; Hisada, S; Ahmed, F; Huntley, R; Sajjadi-Hashemi, Z; Jenkins, DM; Kargbo, RB; Cui, W; Gauuan, PJ; Walker, JR; Decornez, H; Gurram, M Tricyclic compounds and PBK inhibitors containing the same US Patent  US8962648 Publication Date 2/24/2015 
Target
Name:
Lymphokine-activated killer T-cell-originated protein kinase
Synonyms:
2.7.12.2 | CT84 | Cancer/testis antigen 84 | MAPKK-like protein kinase | Nori-3 | PBK | PDZ-binding kinase | SPK | Spermatogenesis-related protein kinase | T-LAK cell-originated protein kinase | TOPK | TOPK_HUMAN
Type:
n/a
Mol. Mass.:
36072.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
322
Sequence:
MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV
  
Inhibitor
Name:
BDBM149044
Synonyms:
US8962648, 278
Type:
Small organic molecule
Emp. Form.:
C22H19FN2O3S
Mol. Mass.:
410.461
SMILES:
OC1CCN(Cc2ccc(cc2F)-c2c(O)ccc3[nH]c(=O)c4sccc4c23)C1
Structure:
Search PDB for entries with ligand similarity: