Target
Neuraminidase
Ligand
BDBM4958
Substrate
BDBM4702
Meas. Tech.
Neuraminidase Inhibition Assay
IC50
14±n/a nM
Citation
 Smith, PWSollis, SLHowes, PDCherry, PCStarkey, IDCobley, KNWeston, HScicinski, JMerritt, AWhittington, AWyatt, PTaylor, NGreen, DBethell, RMadar, SFenton, RJMorley, PJPateman, TBeresford, A Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides. J Med Chem 41:787-97 (1998) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
Influenza A Virus Neuraminidase | NA | NRAM_I57A5 | Neuraminidase A
Type:
Enzyme
Mol. Mass.:
52000.86
Organism:
Influenza A virus (A/Singapore/1/57(H2N2))
Description:
Q6XUE4
Residue:
469
Sequence:
MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHECDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIKEGKIVHISPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNRPVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDVWMGRTINKDSRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
  
Inhibitor
Name:
BDBM4958
Synonyms:
(2R,3R,4S)-4-amino-3-acetamido-2-[(2-methylpropyl)(2-phenylethyl)carbamoyl]-3,4-dihydro-2H-pyran-6-carboxylic acid | CHEMBL165651 | carboxamide deriv. 4aa
Type:
Small organic molecule
Emp. Form.:
C21H29N3O5
Mol. Mass.:
403.4721
SMILES:
[H][C@]1(OC(=C[C@H](N)[C@H]1NC(C)=O)C(O)=O)C(=O)N(CCc1ccccc1)CC(C)C |r,c:3|
Structure:
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Substrate
Name:
BDBM4702
Synonyms:
(2R,4S,5R,6R)-5-acetamido-4-hydroxy-2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid | 2 -(4-methylumbelliferyl)-alpha-D-acetylneuraminic acid | neuraminidase substrate
Type:
Small organic molecule
Emp. Form.:
C21H25NO11
Mol. Mass.:
467.4233
SMILES:
CC(=O)N[C@@H]1[C@@H](O)C[C@](Oc2ccc3c(C)cc(=O)oc3c2)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O |r|
Structure:
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