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Target
Translocator protein
Ligand
BDBM150168
Substrate
n/a
Meas. Tech.
Competitive Binding Assay
Temperature
303.15±n/a K
Ki
6.66±n/a nM
IC50
15.64±n/a nM
Comments
extracted
Citation
 Yang, R; Li, Y; Li, Y; Zhao, N; Yun, L; Qin, J; Feng, Z; Zhang, Y 2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof US Patent  US8980887 Publication Date 3/17/2015 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM150168
Synonyms:
US8980887, Compound 11
Type:
Small organic molecule
Emp. Form.:
C25H24Cl2N4O2
Mol. Mass.:
483.39
SMILES:
COCCN(Cc1ccccn1)C(=O)Cc1c(nc2cc(C)ccn12)-c1ccc(Cl)c(Cl)c1
Structure:
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