Reaction Details
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Replicase polyprotein 1ab [1541-1855]
Ligand
BDBM31530
Substrate
n/a
Meas. Tech.
Fluorimetric Assay
pH
7.5±n/a
IC50
1.18e+3± 8e+1 nM
Comments
extracted
Citation
Lee, H; Lei, H; Santarsiero, BD; Gatuz, JL; Cao, S; Rice, AJ; Patel, K; Szypulinski, MZ; Ojeda, I; Ghosh, AK; Johnson, ME Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV. ACS Chem Biol 10:1456-65 (2015) [PubMed] Article More Info.:
Target
Name:
Replicase polyprotein 1ab [1541-1855]
Synonyms:
R1AB_SARS | SARS Coronavirus Coronavirus Papain-Like Protease | SARS-CoV PLpro | SARS-CoV papain-like protease (SARS-PLpro) | rep
Type:
Hydrolase
Mol. Mass.:
35352.30
Organism:
Human SARS coronavirus (SARS-CoV)
Description:
The SARS-CoV PLpro enzyme (residues 1541 -1855) was expressed and purified from E. coli.
Residue:
315
Sequence:
EVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK
Inhibitor
Name:
BDBM31530
Synonyms:
2-methyl-5-[(methylamino)methyl]-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide (I-2) | Substituted Benzamide Derivative, 49 | med.21724, Compound 164
Type:
Small organic molecule
Emp. Form.:
C22H24N2O
Mol. Mass.:
332.4388
SMILES:
CNCc1ccc(C)c(c1)C(=O)N[C@H](C)c1cccc2ccccc12 |r|
Structure:
