Reaction Details Report a problem with these data
Target
N-glycosylase/DNA lyase
Ligand
BDBM163679
Substrate
n/a
Meas. Tech.
Fluorescence-based Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
3.5e+2± 5e+1 nM
Comments
extracted
Citation
 Donley, N; Jaruga, P; Coskun, E; Dizdaroglu, M; McCullough, AK; Lloyd, RS Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol 10:2334-43 (2015) [PubMed]  Article 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Homo sapiens (Human)
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM163679
Synonyms:
3,4‐Dichloro‐1‐benzothiophene‐2‐carbohydrazide (08)
Type:
Small organic molecule
Emp. Form.:
C9H6Cl2N2OS
Mol. Mass.:
261.128
SMILES:
NNC(=O)c1sc2cccc(Cl)c2c1Cl
Structure:
Search PDB for entries with ligand similarity: