Reaction Details Report a problem with these data
Target
Adenosine receptor A3 [I248L]
Ligand
BDBM50310925
Substrate
n/a
Meas. Tech.
Fluorometric Imaging Plate Reader (FLIPR) Asssay
IC50
130.3±n/a nM
Citation
 Jordan, A; Bedford, S; Burkhard, K; Yule, I; Poullennec, K Thienopyrimidine compounds US Patent  US9120807 Publication Date 9/1/2015 
Target
Name:
Adenosine receptor A3 [I248L]
Synonyms:
AA3R_HUMAN | ADORA3 | Adenosine receptor A3 | Adenosine receptor A3 (A3)
Type:
Protein
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8[I248L]
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSLINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50310925
Synonyms:
CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-[(pyridine-3-ylmethyl)-amino]-thieno[3,2-d]pyrimidin-4-yl}-thiophen-2-yl-methanone
Type:
Small organic molecule
Emp. Form.:
C19H17N5OS2
Mol. Mass.:
395.501
SMILES:
CN(C)c1cc2nc(NCc3cccnc3)nc(C(=O)c3cccs3)c2s1
Structure:
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