Target
Mitogen-activated protein kinase 1
Ligand
BDBM180930
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
3.8±n/a nM
Comments
extracted
Citation
 Blake, JFChen, HChicarelli, MJDemeese, JGarrey, RGaudino, JJKaus, RJKolakowski, GRMarlow, ALMohr, PJRen, LSchwarz, JSiedem, CSThomas, AAWallace, EWenglowsky, SMBoyd, S Serine/threonine kinase inhibitors US Patent  US9133187 Publication Date 9/15/2015 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM180930
Synonyms:
US9133187, I-3
Type:
Small organic molecule
Emp. Form.:
C24H27ClFN7O2
Mol. Mass.:
499.968
SMILES:
Cn1ccc(n1)C(NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1
Structure:
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