Target
Mitogen-activated protein kinase 1
Ligand
BDBM180945
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
1.6±n/a nM
Comments
extracted
Citation
 Blake, JFChen, HChicarelli, MJDemeese, JGarrey, RGaudino, JJKaus, RJKolakowski, GRMarlow, ALMohr, PJRen, LSchwarz, JSiedem, CSThomas, AAWallace, EWenglowsky, SMBoyd, S Serine/threonine kinase inhibitors US Patent  US9133187 Publication Date 9/15/2015 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM180945
Synonyms:
US9133187, I-50
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2F2N5O2
Mol. Mass.:
486.342
SMILES:
C[C@@H](NC(=O)N1Cc2nc(NC3CCOCC3)ncc2C(F)(F)C1)c1ccc(Cl)c(Cl)c1 |r|
Structure:
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