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Target
Mitogen-activated protein kinase 1
Ligand
BDBM180982
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
2.4±n/a nM
Comments
extracted
Citation
 Blake, JF; Chen, H; Chicarelli, MJ; Demeese, J; Garrey, R; Gaudino, JJ; Kaus, RJ; Kolakowski, GR; Marlow, AL; Mohr, PJ; Ren, L; Schwarz, J; Siedem, CS; Thomas, AA; Wallace, E; Wenglowsky, SM; Boyd, S Serine/threonine kinase inhibitors US Patent  US9133187 Publication Date 9/15/2015 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM180982
Synonyms:
US9133187, II-51
Type:
Small organic molecule
Emp. Form.:
C23H26ClFN8O
Mol. Mass.:
484.957
SMILES:
CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@H](CNc1ccncn1)c1ccc(F)c(Cl)c1 |r|
Structure:
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