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Target
Mitogen-activated protein kinase 1
Ligand
BDBM181006
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
3.15±n/a nM
Comments
extracted
Citation
 Blake, JF; Chen, H; Chicarelli, MJ; Demeese, J; Garrey, R; Gaudino, JJ; Kaus, RJ; Kolakowski, GR; Marlow, AL; Mohr, PJ; Ren, L; Schwarz, J; Siedem, CS; Thomas, AA; Wallace, E; Wenglowsky, SM; Boyd, S Serine/threonine kinase inhibitors US Patent  US9133187 Publication Date 9/15/2015 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM181006
Synonyms:
US9133187, II-371
Type:
Small organic molecule
Emp. Form.:
C20H23Cl2N5O2
Mol. Mass.:
436.335
SMILES:
C[C@@H](NC(=O)N1CCc2cnc(N[C@@H]3C[C@H](O)C3)nc2C1)c1ccc(Cl)c(Cl)c1 |r,wU:13.12,15.15,wD:1.0,(4.56,1.65,;4.56,.11,;3.23,-.66,;1.9,.11,;1.9,1.65,;.56,-.66,;.56,-2.2,;-.77,-2.97,;-2.1,-2.2,;-3.44,-2.97,;-4.77,-2.2,;-4.77,-.66,;-6.1,.11,;-6.1,1.65,;-5.02,2.74,;-6.1,3.83,;-6.1,5.37,;-7.19,2.74,;-3.44,.11,;-2.1,-.66,;-.77,.11,;5.9,-.66,;7.23,.11,;8.57,-.66,;8.57,-2.2,;9.9,-2.97,;7.23,-2.97,;7.23,-4.51,;5.9,-2.2,)|
Structure:
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