Reaction Details Report a problem with these data
Target
Dihydrolipoyl dehydrogenase
Ligand
BDBM54927
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7±n/a
IC50
100±n/a nM
Comments
extracted
Citation
 Wong, C; Wu, Y Compounds and methods for treating tuberculosis infection US Patent  US9073941 Publication Date 7/7/2015 
Target
Name:
Dihydrolipoyl dehydrogenase
Synonyms:
DLDH_MYCTU | Lipoamide Dehydrogenase (Lpd) | lpd | lpdC
Type:
Enzyme
Mol. Mass.:
49231.98
Organism:
Mycobacterium tuberculosis
Description:
P9WHH9
Residue:
464
Sequence:
MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAELVHIFTKDAKAFGISGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTATKVESIADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMINF
  
Inhibitor
Name:
BDBM54927
Synonyms:
4-(benzylamino)-1,2-naphthoquinone | 4-(benzylamino)naphthalene-1,2-dione | 4-[(phenylmethyl)amino]naphthalene-1,2-dione | MLS000712297 | SMR000282064 | US9073941, 901 | cid_3095209
Type:
Small organic molecule
Emp. Form.:
C17H13NO2
Mol. Mass.:
263.2906
SMILES:
O=C1C=C(NCc2ccccc2)c2ccccc2C1=O |t:2|
Structure:
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