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Target
5'-AMP-activated protein kinase catalytic subunit alpha-1
Ligand
BDBM192514
Substrate
n/a
Meas. Tech.
AMPK Activation Assay
pH
7±n/a
EC50
26±n/a nM
Citation
 Wagner, H; Himmelsbach, F Azabenzimidazole derivatives US Patent  US9187477 Publication Date 11/17/2015 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-1
Synonyms:
AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1
Type:
Protein
Mol. Mass.:
64023.62
Organism:
Homo sapiens (Human)
Description:
Q13131
Residue:
559
Sequence:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
  
Inhibitor
Name:
BDBM192514
Synonyms:
US9187477, 10
Type:
Small organic molecule
Emp. Form.:
C27H31ClN4O6
Mol. Mass.:
543.011
SMILES:
CCNC(=O)O[C@H]1CC[C@H](CC1)c1ccc(cc1)-c1nc2[nH]c(O[C@@H]3COC4[C@H](O)COC34)nc2cc1Cl |r,wU:9.12,24.25,28.30,6.5,(-12.36,6.35,;-11.03,5.58,;-11.03,4.04,;-9.69,3.27,;-9.69,1.73,;-8.36,4.04,;-7.03,3.27,;-5.69,4.04,;-4.36,3.27,;-4.36,1.73,;-5.69,.96,;-7.03,1.73,;-3.31,1.01,;-1.98,1.78,;-.65,1.01,;-.65,-.53,;-1.98,-1.3,;-3.31,-.53,;.69,-1.3,;2.02,-.53,;3.35,-1.3,;4.82,-.82,;5.72,-2.07,;7.26,-2.07,;8.03,-3.4,;7.56,-4.87,;8.8,-5.77,;10.05,-4.87,;11.59,-4.87,;12.36,-6.2,;12.07,-3.4,;10.82,-2.5,;9.57,-3.4,;4.82,-3.31,;3.35,-2.84,;2.02,-3.61,;.69,-2.84,;-.65,-3.61,)|
Structure:
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