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Target
Lipoxygenase
Ligand
BDBM192704
Substrate
n/a
Meas. Tech.
In-vitro LOX Inhibition Assay
pH
9±n/a
Temperature
298.15±n/a K
IC50
15.503±2.553 nM
Comments
extracted
Citation
 Srivastava, P; Vyas, VK; Variya, B; Patel, P; Qureshi, G; Ghate, M Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives. Bioorg Chem 67:130-8 (2016) [PubMed]  Article 
Target
Name:
Lipoxygenase
Synonyms:
5-Lipoxygenase (5-LOX)
Type:
Protein
Mol. Mass.:
97266.07
Organism:
Glycine max (Soybean)
Description:
n/a
Residue:
866
Sequence:
MFSVPGVSGILNRGGGHKIKGTVVLMRKNVLDFNSVADLTKGNVGGLIGTGLNVVGSTLDNLTAFLGRSVALQLISATKPLANGKGKVGKDTFLEGIIVSLPTLGAGESAFNIQFEWDESMGIPGAFYIKNYMQVEFYLKSLTLEDVPNQGTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAALVGYREEELKNLRGDGKGERKEHDRIYDYDVYNDLGNPDHGENFARPILGGSSTHPYPRRGRTGRYPTRKDQNSEKPGEVYVPRDENFGHLKSSDFLAYGIKSLSQYVLPAFESVFDLNFTPNEFDSFQDVRDLHEGGIKLPTEVISTIMPLPVVKELFRTDGEQVLKFPPPHVIQVSKSAWMTDEEFAREMVAGVNPCVIRGLQEFPPKSNLDPTIYGEQTSKITADALDLDGYTVDEALASRRLFMLDYHDVFMPYIRRINQTYAKAYATRTILFLRENGTLKPVAIELSLPHPAGDLSGAVSQVILPAKEGVESTIWLLAKAYVVVNDSCYHQLMSHWLNTQAVIEPFIIATNRHLSALHPIYKLLTPHYRDTMNINALARQSLINADGIIEKSFLPSKHSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSAPHGLRLLIEDYPYAVDGLEIWAAIKTWVQEYVSLYYARDDDVKPDSELQQWWKEAVEKGHGDLKDKPWWPKLQTIEELVEICTIIIWTASALHAAVNFGQYPYGGFILNRPTSSRRLLPEKGTPEYEEMVKSHQKAYLRTITSKFQTLVDLSVIEILSRHASDEVYLGQRDNPHWTSDSKALQAFQKFGNKLKEIEEKLARKNNDQSLSNRLGPVQLPYTLLHPNSEEGLTCRGIPNSISI
  
Inhibitor
Name:
BDBM192704
Synonyms:
7-(3-(5,6-dichlorobenzo[d]thiazol-2-ylamino)-2-hydroxypropoxy)-4-methyl-2H-chromen-2-one (34)
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N2O4S
Mol. Mass.:
451.323
SMILES:
Cc1cc(=O)oc2cc(OCC(O)CNc3nc4cc(Cl)c(Cl)cc4s3)ccc12
Structure:
Search PDB for entries with ligand similarity: