Reaction Details Report a problem with these data
Target
Lysophospholipase-like protein 1
Ligand
BDBM195581
Substrate
n/a
Meas. Tech.
Gel-based ABPP (LYPLAL1)
pH
7.5±n/a
IC50
5±n/a nM
Comments
extracted
Citation
Ahn, K; Boehm, M; Brown, MF; Calloway, J; Che, Y; Chen, J; Fennell, KF; Geoghegan, KF; Gilbert, AM; Gutierrez, JA; Kalgutkar, AS; Lanba, A; Limberakis, C; Magee, TV; O'Doherty, I; Oliver, R; Pabst, B; Pandit, J; Parris, K; Pfefferkorn, JA; Rolph, TP; Patel, R; Schuff, B; Shanmugasundaram, V; Starr, JT; Varghese, AH; Vera, NB; Vernochet, C; Yan, J Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol 11:2529-40 (2016) [PubMed] Article
More Info.:
Target
Name:
Lysophospholipase-like protein 1
Synonyms:
LYPL1_HUMAN | LYPLAL1 | Lysophospholipase-like 1 (LYPLAL1)
Type:
Protein
Mol. Mass.:
26322.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
237
Sequence:
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
Inhibitor
Name:
BDBM195581
Synonyms:
(2R,3R)-2-(3-ethynylphenyl)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1,2,4-triazole-1-carbonyl)piperidine-3-carboxylic acid (12)
Type:
Small organic molecule
Emp. Form.:
C31H29N7O4
Mol. Mass.:
563.6065
SMILES:
OC(=O)[C@@H]1CCCN([C@H]1c1cccc(c1)C#C)C(=O)n1cnc(n1)-c1ccc(cc1)-c1cnc(nc1)N1CCOCC1