Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase B chain
Ligand
BDBM197160
Substrate
n/a
Meas. Tech.
LHDA/LDHB Enzymatic Assays
IC50
5±n/a nM
Citation
 Boudreau, A; Purkey, HE; Hitz, A; Robarge, K; Peterson, D; Labadie, S; Kwong, M; Hong, R; Gao, M; Del Nagro, C; Pusapati, R; Ma, S; Salphati, L; Pang, J; Zhou, A; Lai, T; Li, Y; Chen, Z; Wei, B; Yen, I; Sideris, S; McCleland, M; Firestein, R; Corson, L; Vanderbilt, A; Williams, S; Daemen, A; Belvin, M; Eigenbrot, C; Jackson, PK; Malek, S; Hatzivassiliou, G; Sampath, D; Evangelista, M; O'Brien, T Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol 12:779-86 (2016) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM197160
Synonyms:
GNE-140 (6)
Type:
Small organic molecule
Emp. Form.:
C25H23ClN2O3S2
Mol. Mass.:
499.045
SMILES:
OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1 |r,c:1|
Structure:
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