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Target
Serine/threonine-protein kinase WNK3 [1-434]
Ligand
BDBM207990
Substrate
n/a
Meas. Tech.
WNK In Vitro Radiometric Assays
pH
7.3±n/a
IC50
377±n/a nM
Comments
extracted
Citation
 Yamada, K; Zhang, JH; Xie, X; Reinhardt, J; Xie, AQ; LaSala, D; Kohls, D; Yowe, D; Burdick, D; Yoshisue, H; Wakai, H; Schmidt, I; Gunawan, J; Yasoshima, K; Yue, QK; Kato, M; Mogi, M; Idamakanti, N; Kreder, N; Drueckes, P; Pandey, P; Kawanami, T; Huang, W; Yagi, YI; Deng, Z; Park, HM Discovery and Characterization of Allosteric WNK Kinase Inhibitors. ACS Chem Biol 11:3338-3346 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase WNK3 [1-434]
Synonyms:
KIAA1566 | PRKWNK3 | WNK3 | WNK3_HUMAN | With-No-Lysine kinase 3 (WNK3)
Type:
Protein
Mol. Mass.:
49299.18
Organism:
Homo sapiens (Human)
Description:
WNK3 truncation (1-434 aa)
Residue:
434
Sequence:
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVED
  
Inhibitor
Name:
BDBM207990
Synonyms:
(2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)thiazol-4-yl)indolin-1-yl)methanone (Compound 2)
Type:
Small organic molecule
Emp. Form.:
C26H22ClN3O2S
Mol. Mass.:
475.99
SMILES:
CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: