Reaction Details Report a problem with these data
Target
Acyl-protein thioesterase 1
Ligand
BDBM207991
Substrate
n/a
Meas. Tech.
Steady-State Kinetic Assays
pH
6.5±n/a
Ki
280±33 nM
Comments
extracted
Citation
 Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
APT-1 | APT1 | Acyl-protein thioesterase 1 (APT1 WT) | LPL-I | LPL1 | LYPA1_HUMAN | LYPLA1 | LysoPLA I | Lysophospholipase 1 | Lysophospholipase I | hAPT1
Type:
Protein
Mol. Mass.:
24670.33
Organism:
Homo sapiens (Human)
Description:
O75608
Residue:
230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
  
Inhibitor
Name:
BDBM207991
Synonyms:
ML348
Type:
Small organic molecule
Emp. Form.:
C18H17ClF3N3O3
Mol. Mass.:
415.794
SMILES:
FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
Structure:
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