Target
Acyl-protein thioesterase 1 [L176M]
Ligand
BDBM207991
Substrate
n/a
Meas. Tech.
Steady-State Kinetic Assays
pH
6.5±n/a
Ki
340±40 nM
Comments
extracted
Citation
 Won, SJDavda, DLabby, KJHwang, SYPricer, RMajmudar, JDArmacost, KARodriguez, LARodriguez, CLChong, FSTorossian, KAPalakurthi, JHur, ESMeagher, JLBrooks, CLStuckey, JAMartin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol 11:3374-3382 (2016) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1 [L176M]
Synonyms:
APT1 | Acyl-protein thioesterase 1 (APT1 L176M) | LPL1 | LYPA1_HUMAN | LYPLA1
Type:
Protein
Mol. Mass.:
24688.37
Organism:
Homo sapiens (Human)
Description:
Human APT1 with L176M mutation
Residue:
230
Sequence:
MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPMVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
  
Inhibitor
Name:
BDBM207991
Synonyms:
ML348
Type:
Small organic molecule
Emp. Form.:
C18H17ClF3N3O3
Mol. Mass.:
415.794
SMILES:
FC(F)(F)c1ccc(Cl)c(NC(=O)CN2CCN(CC2)C(=O)c2ccco2)c1
Structure:
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