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TargetEphrin type-A receptor 2 (EPHA2)
LigandBDBM50382959
Substrate/Competitorn/a
Meas. Tech.HotSpot Kinase Activity Assay
IC50 28±0.0 nM
Citation Heinzlmeir, SKudlinzki, DSreeramulu, SKlaeger, SGande, SLLinhard, VWilhelm, MQiao, HHelm, DRuprecht, BSaxena, KMédard, GSchwalbe, HKuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ephrin type-A receptor 2 (EPHA2)
Name:Ephrin type-A receptor 2 (EPHA2)
Synonyms:n/a
Type:Protein
Mol. Mass.:34367.96
Organism:Homo sapiens (Human)
Description:EPHA2 truncation (596-900 aa); 519U
Residue:305
Sequence:
DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK
QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ
LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS
GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR
LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRL
PSTSG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50382959
NameBDBM50382959
Synonyms:CEP-32496 | CHEMBL2029988 | US9730937, Example 261
TypeSmall organic molecule
Emp. Form.C24H22F3N5O5
Mol. Mass.517.4572
SMILESCOc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC
Structure
n/a