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Target
CD63 antigen
Ligand
BDBM212270
Substrate
n/a
Meas. Tech.
High Throughput Syk Biochemical Assay
pH
7±n/a
IC50
51±n/a nM
Comments
extracted
Citation
 Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Lo, JR; Mitchell, SA; Schmitt, AC; Xiong, J; Xu, J; Zhao, Z; Swaminathan, S Substituted imidazo[1,2-a]pyrazines as Syk inhibitors US Patent  US9290505 Publication Date 3/22/2016 
Target
Name:
CD63 antigen
Synonyms:
CD63 | CD63_HUMAN | CD_antigen: CD63 | CD_antigen=CD63 | Granulophysin | LAMP-3 | Limp1 | Lysosomal-associated membrane protein 3 | Lysosome integral membrane protein 1 | MLA1 | Melanoma-associated antigen ME491 | OMA81H | Ocular melanoma-associated antigen | TSPAN30 | Tetraspanin-30 | Tspan-30
Type:
n/a
Mol. Mass.:
25640.41
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
238
Sequence:
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM
  
Inhibitor
Name:
BDBM212270
Synonyms:
6-(6-amino-5-methylpyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine | US10342794, Example Ex.-1 | US10828299, Example Ex.-1 | US11517570, Example Ex.-1: | US9290505, Ex.-1 | US9504684, Ex.-1 | US9931338, Ex.-1
Type:
Small organic molecule
Emp. Form.:
C24H27N9O
Mol. Mass.:
457.5309
SMILES:
Cc1ncc(nc1N)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
Structure:
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