Reaction Details Report a problem with these data
Target
CD63 antigen
Ligand
BDBM212276
Substrate
n/a
Meas. Tech.
High Throughput Syk Biochemical Assay
pH
7±n/a
IC50
167±n/a nM
Comments
extracted
Citation
Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Lo, JR; Mitchell, SA; Schmitt, AC; Xiong, J; Xu, J; Zhao, Z; Swaminathan, S Substituted imidazo[1,2-a]pyrazines as Syk inhibitors US Patent US9290505 Publication Date 3/22/2016
More Info.:
Target
Name:
CD63 antigen
Synonyms:
CD63 | CD63_HUMAN | CD_antigen: CD63 | CD_antigen=CD63 | Granulophysin | LAMP-3 | Limp1 | Lysosomal-associated membrane protein 3 | Lysosome integral membrane protein 1 | MLA1 | Melanoma-associated antigen ME491 | OMA81H | Ocular melanoma-associated antigen | TSPAN30 | Tetraspanin-30 | Tspan-30
Type:
n/a
Mol. Mass.:
25640.41
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
238
Sequence:
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM
Inhibitor
Name:
BDBM212276
Synonyms:
2-(5-((6-(6-amino-5-methylpyrazin-2-yl)imidazo[1,2-a]pyrazin-8-yl)amino)-2-(4-(oxetan-3-yl)piperazin-1-yl)phenoxy)ethanol | US10342794, Example Ex.-7 | US10828299, Example Ex.-7 | US11517570, Example Ex.-7: | US9290505, Ex.-7 | US9504684, Ex.-7 | US9931338, Ex.-7
Type:
Small organic molecule
Emp. Form.:
C26H31N9O3
Mol. Mass.:
517.5828
SMILES:
Cc1ncc(nc1N)-c1cn2ccnc2c(Nc2ccc(N3CCN(CC3)C3COC3)c(OCCO)c2)n1