Target
Acetyl-CoA carboxylase 2 [129-967]
Ligand
BDBM212610
Substrate
n/a
Meas. Tech.
Spectrophotometric 384 Well Assay
pH
7.5±n/a
IC50
57±n/a nM
Comments
extracted
Citation
 Heine, NFleck, MNosse, BRoth, GJ Pyrrolidine derivatives, pharmaceutical compositions and uses thereof US Patent  US9278954 Publication Date 3/8/2016 
Target
Name:
Acetyl-CoA carboxylase 2 [129-967]
Synonyms:
ACACB | ACACB_HUMAN | ACC2 | ACCB | Acetyl-CoA carboxylase 2 (ACC2)
Type:
Enzyme
Mol. Mass.:
92599.28
Organism:
Homo sapiens (Human)
Description:
O00763 lacks the 128 amino acids at the N-terminus
Residue:
839
Sequence:
DTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPS
  
Inhibitor
Name:
BDBM212610
Synonyms:
US9278954, 1.1 | US9278954, 6.1 isomer 1 | US9278954, 6.1 isomer 2
Type:
Small organic molecule
Emp. Form.:
C24H31ClN4O4
Mol. Mass.:
474.98
SMILES:
CC(C(=O)NC1CC1)c1ccc(O[C@@H]2CCN(C2)c2ncnc(OCC(C)(C)O)c2Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: