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Target
Inositol-pentakisphosphate 2-kinase
Ligand
BDBM213230
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
7.5±0
Temperature
298.15±0 K
Kd
8.20e+3±n/a nM
Citation
 Gosein, V; Miller, GJ Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation. J Biol Chem 288:26908-13 (2013) [PubMed]  Article 
Target
Name:
Inositol-pentakisphosphate 2-kinase
Synonyms:
IPK1 | IPPK_ARATH | Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1)
Type:
Enzyme
Mol. Mass.:
50507.86
Organism:
Arabidopsis thaliana (Mouse-ear cress)
Description:
Q93YN9
Residue:
451
Sequence:
MEMILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQKARRNDKAIKNANGVVSVLTSDEQHLWRENNELISSPNKEVLEQRYVKNVIIPLLGPKHVDAGVRVSVSKEFLECVDKKVTKQRPLWRVNAANVDTSHDSALILNDHSLFSQGISSGGDCISVEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKLEYNEISEESEYDPLDLFSGSKESVLEAIKALYSTPQNNFRVFLNGSLILGGSGESTGRTSPEIGYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVLDRLLEIQKLDKLDIEGAIHSYYDLINQPCPICKEGKPLEAELSLHALPLDESLKIVKEYLIAATAKDCSIMISFQSRNAWDSEPSGDYVSLKPTNQTFDYKVHFIDLSLKPLKRMESYYKLDKKIISFYNRKQKAENTAEQIGNSKPSHS
  
Inhibitor
Name:
BDBM213230
Synonyms:
1,4,5,6-Inositol tetrakisphosphate (1,4,5,6-IP4)
Type:
Small organic molecule
Emp. Form.:
C6H8O18P4
Mol. Mass.:
492.0164
SMILES:
O[C@H]1[C@@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](OP([O-])([O-])=O)[C@@H]1OP([O-])([O-])=O
Structure:
Search PDB for entries with ligand similarity: