Reaction Details Report a problem with these data
Target
Histidine-binding periplasmic protein [1-238]
Ligand
BDBM7953
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry (ITC)
pH
7±0
Temperature
303.15±0 K
Kd
114±16 nM
Citation
 Chu, BC; DeWolf, T; Vogel, HJ Role of the two structural domains from the periplasmic Escherichia coli histidine-binding protein HisJ. J Biol Chem 288:31409-22 (2013) [PubMed]  Article 
Target
Name:
Histidine-binding periplasmic protein [1-238]
Synonyms:
HISJ_ECOLI | Histidine-binding periplasmic protein (HisJ) | hisJ
Type:
Protein
Mol. Mass.:
25923.66
Organism:
Escherichia coli (Enterobacteria)
Description:
E. coli HisJ truncation (1-238 aa) without periplasmic signal sequence
Residue:
238
Sequence:
MKKLVLSLSLVLAFSSATAAFAAIPQNIRIGTDPTYAPFESKNSQGELVGFDIDLAKELCKRINTQCTFVENPLDALIPSLKAKKIDAIMSSLSITEKRQQEIAFTDKLYAADSRLVVAKNSDIQPTVESLKGKRVGVLQGTTQETFGNEHWAPKGIEIVSYQGQDNIYSDLTAGRIDAAFQDEVAASEGFLKQPVGKDYKFGGPSVKDEKLFGVGTGMGLRKEDNELREALNKAFAE
  
Inhibitor
Name:
BDBM7953
Synonyms:
(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid | Histidine | Imidazole C-4(5) deriv. 5 | L-2-Amino-3-(4-imidazolyl)propionic acid | L-Histidine
Type:
Small organic molecule
Emp. Form.:
C6H9N3O2
Mol. Mass.:
155.1546
SMILES:
N[C@@H](Cc1cnc[nH]1)C(O)=O |r|
Structure:
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