Target
Synaptic vesicular amine transporter [P314T]
Ligand
BDBM50017712
Substrate
n/a
Meas. Tech.
[3H]Serotonin Uptake Assay
pH
8.5±n/a
IC50
4.3±0.1 nM
Comments
extracted
Citation
 Ugolev, YSegal, TYaffe, DGros, YSchuldiner, S Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem 288:32160-71 (2013) [PubMed]  Article 
Target
Name:
Synaptic vesicular amine transporter [P314T]
Synonyms:
Slc18a2 | Svat | VMAT2_RAT | Vesicular monoamine transporter 2 (VMAT P314T) | Vmat2
Type:
Protein
Mol. Mass.:
55693.57
Organism:
Rattus norvegicus (Rat)
Description:
Rat VMAT2 P314T mutant
Residue:
515
Sequence:
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLETALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
  
Inhibitor
Name:
BDBM50017712
Synonyms:
(-)-reserpine | (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester | 3,4,5-trimethoxybenzoyl methyl reserpate | Apoplon | CHEMBL772 | NCGC00091250 | RESERPINE | Reserpin | Serpalan | cid_5770 | methyl (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
Type:
Small organic molecule
Emp. Form.:
C33H40N2O9
Mol. Mass.:
608.6787
SMILES:
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c1cc(OC)c(OC)c(OC)c1 |r|
Structure:
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