Reaction Details Report a problem with these data
Target
Arginase-1
Ligand
BDBM290428
Substrate
n/a
Meas. Tech.
Inhibition Assay of Arginase
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
<250±n/a nM
Comments
extracted
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US10098902 Publication Date 10/16/2018 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290428
Synonyms:
(1S,2S,4R)-1-amino-4-(aminomethyl)-2-(3- boronopropyl)cyclopentanecarboxylic acid | US10098902, Example 64 | US10603330, Example 64 | US11389464, Example 64
Type:
Small organic molecule
Emp. Form.:
C10H21BN2O4
Mol. Mass.:
244.096
SMILES:
NC[C@@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: