Reaction Details Report a problem with these data
Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM222219
Substrate
n/a
Meas. Tech.
α-Glucosidase Inhibition Assay
IC50
7.81e+3± 1 nM
Citation
 Chaudhry, F; Naureen, S; Huma, R; Shaukat, A; Al-Rashida, M; Asif, N; Ashraf, M; Munawar, MA; Khan, MA In search of new a-glucosidase inhibitors: Imidazolylpyrazole derivatives. Bioorg Chem 71:102-109 (2017) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM222219
Synonyms:
4-(4,5-Diphenyl-1H-imidazol-2-yl)-1-(4-nitrophenyl)-3-phenyl-1H-pyrazole (2h)
Type:
Small organic molecule
Emp. Form.:
C30H21N5O2
Mol. Mass.:
483.52
SMILES:
[O-][N+](=O)c1ccc(cc1)-n1cc(-c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)c(n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: