Reaction Details Report a problem with these data
Target
Beta-galactosidase [24-677]
Ligand
BDBM50163440
Substrate
4-Methylumbelliferyl-β-D-galactopyranoside
Meas. Tech.
β-Gal Inhibitory Assay
pH
4.5±n/a
Temperature
310.15±n/a K
Ki
6.18e+4±n/a nM
Citation
Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem 289:14560-8 (2014) [PubMed] Article
More Info.:
Target
Name:
Beta-galactosidase [24-677]
Synonyms:
BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase (β-Gal)
Type:
Enzyme
Mol. Mass.:
73588.24
Organism:
Homo sapiens (Human)
Description:
Human β-Gal (24-677 aa)
Residue:
654
Sequence:
LRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
Inhibitor
Name:
BDBM50163440
Synonyms:
(2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | 1-deoxygalactonojirimycin | CHEMBL110458 | D-galacto-1-Deoxynojirimycin | DGJ
Type:
Small organic molecule
Emp. Form.:
C6H13NO4
Mol. Mass.:
163.1717
SMILES:
OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O |r|