Target
Tyrosine-protein phosphatase non-receptor type 9 [277-582]
Ligand
BDBM231167
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
pH
7±n/a
Ki
34±2 nM
IC50
75±10 nM
Comments
extracted
Citation
 Zhang, ZZhang, S Inhibitors of protein tyrosine phosphatases US Patent  US9340574 Publication Date 5/17/2016 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 9 [277-582]
Synonyms:
PTN9_HUMAN | PTPN9 | Tyrosine-protein phosphatase non-receptor type 9 (PTP-MEG2)
Type:
Protein
Mol. Mass.:
35160.61
Organism:
Homo sapiens (Human)
Description:
residues 277-582
Residue:
306
Sequence:
SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVS
  
Inhibitor
Name:
BDBM231167
Synonyms:
US9340574, 7
Type:
Small organic molecule
Emp. Form.:
C42H45BrF2IN6O11P
Mol. Mass.:
1085.619
SMILES:
COc1cc(CC(=O)NCC(NC(=O)C(CCCNC(=O)c2cccc(I)c2)NC(=O)C(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)NC(=O)c2ccc(C)c(Br)c2)C(N)=O)ccc1O
Structure:
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