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Target
Receptor-type tyrosine-protein phosphatase epsilon
Ligand
BDBM231167
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
pH
7±n/a
IC50
>10000±n/a nM
Comments
extracted
Citation
 Zhang, Z; Zhang, S Inhibitors of protein tyrosine phosphatases US Patent  US9340574 Publication Date 5/17/2016 
Target
Name:
Receptor-type tyrosine-protein phosphatase epsilon
Synonyms:
PTPRE | PTPRE_HUMAN | Protein-tyrosine phosphatase epsilon | Receptor-type tyrosine-protein phosphatase epsilon | Receptor-type tyrosine-protein phosphatase epsilon (PTPε)
Type:
Protein
Mol. Mass.:
80646.31
Organism:
Homo sapiens (Human)
Description:
P23469
Residue:
700
Sequence:
MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
  
Inhibitor
Name:
BDBM231167
Synonyms:
US9340574, 7
Type:
Small organic molecule
Emp. Form.:
C42H45BrF2IN6O11P
Mol. Mass.:
1085.619
SMILES:
COc1cc(CC(=O)NCC(NC(=O)C(CCCNC(=O)c2cccc(I)c2)NC(=O)C(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)NC(=O)c2ccc(C)c(Br)c2)C(N)=O)ccc1O
Structure:
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