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TargetAbelson tyrosine-kinase 2 SH2 domain (Arg SH2)
LigandBDBM231647
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Assay
pH7.25±n/a
Kd 2.6e+2± 7e+1 nM
Commentsextracted
Citation Gifford, SMLiu, WMader, CCHalo, TLMachida, KBoggon, TJKoleske, AJ Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. J Biol Chem289:19704-13 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Abelson tyrosine-kinase 2 SH2 domain (Arg SH2)
Name:Abelson tyrosine-kinase 2 SH2 domain (Arg SH2)
Synonyms:n/a
Type:Protein
Mol. Mass.:11954.66
Organism:Homo sapiens (Human)
Description:Truncated human Arg (121-226 aa)
Residue:106
Sequence:
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM231647
NameBDBM231647
Synonyms:SSPIpYEDAA | pY421
TypeSmall organic molecule
Emp. Form.C41H62N9O20P
Mol. Mass.1031.953
SMILESCC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O |r|
Structure
n/a