Reaction Details Report a problem with these data
Target
Isocitrate lyase
Ligand
BDBM233149
Substrate
n/a
Meas. Tech.
ICL Enzyme Assay
Temperature
310.15±0 K
IC50
>1.885e+5±n/a nM
Citation
 Sriram, D; Yogeeswari, P; Senthilkumar, P; Naidu, G; Bhat, P 5-Nitro-2,6-dioxohexahydro-4-pyrimidinecarboxamides: synthesis, in vitro antimycobacterial activity, cytotoxicity, and isocitrate lyase inhibition studies. J Enzyme Inhib Med Chem 25:765-72 (2010) [PubMed]  Article 
Target
Name:
Isocitrate lyase
Synonyms:
ACEA_MYCTU | Isocitrase | Isocitratase | Isocitrate lyase | Isocitrate lyase (ICL) | icl
Type:
Enzyme
Mol. Mass.:
47072.93
Organism:
Mycobacterium tuberculosis
Description:
P9WKK7
Residue:
428
Sequence:
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEAVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTGSTEEGQFH
  
Inhibitor
Name:
BDBM233149
Synonyms:
Dacarbazine
Type:
Small organic molecule
Emp. Form.:
C6H10N6O
Mol. Mass.:
182.1832
SMILES:
CN(C)N\N=C1\N=CN=C1C(N)=O |c:6,8|
Structure:
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