Reaction Details
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Seed linoleate 9S-lipoxygenase-3
Ligand
BDBM192757
Substrate
n/a
Meas. Tech.
Lipoxygenase Activity Assay
pH
9±n/a
Temperature
274.15±n/a K
IC50
138900±3100 nM
Comments
extracted
Citation
Sadeghian, H; Seyedi, SM; Attaran, N; Jabbari, A; Jafari, Z Synthesis and SAR comparative studies of 2-allyl-4-methoxy-1-alkoxybenzenes as 15-lipoxygenase inhibitors. J Enzyme Inhib Med Chem 26:238-44 (2011) [PubMed] Article More Info.:
Target
Name:
Seed linoleate 9S-lipoxygenase-3
Synonyms:
15-Lipoxygenase (SLO) | LOX1.3 | LOX3 | LOX3_SOYBN
Type:
Enzyme
Mol. Mass.:
96760.05
Organism:
Glycine max (Soybean)
Description:
P09186
Residue:
857
Sequence:
MLGGLLHRGHKIKGTVVLMRKNVLHVNSVTSVGGIIGQGLDLVGSTLDTLTAFLGRPVSLQLISATKADANGKGKLGKATFLEGIITSLPTLGAGQSAFKINFEWDDGSGILGAFYIKNFMQTEFFLVSLTLEDIPNHGSIHFVCNSWIYNAKLFKSDRIFFANQTYLPSETPAPLVKYREEELHNLRGDGTGERKEWERVYDYDVYNDLGDPDKGENHARPVLGGNDTFPYPRRGRTGRKPTRKDPNSESRSNDVYLPRDEAFGHLKSSDFLTYGLKSVSQNVLPLLQSAFDLNFTPREFDSFDEVHGLYSGGIKLPTDIISKISPLPVLKEIFRTDGEQALKFPPPKVIQVSKSAWMTDEEFAREMLAGVNPNLIRCLKEFPPRSKLDSQVYGDHTSQITKEHLEPNLEGLTVDEAIQNKRLFLLGHHDPIMPYLRRINATSTKAYATRTILFLKNDGTLRPLAIELSLPHPQGDQSGAFSQVFLPADEGVESSIWLLAKAYVVVNDSCYHQLVSHWLNTHAVVEPFIIATNRHLSVVHPIYKLLHPHYRDTMNINGLARLSLVNDGGVIEQTFLWGRYSVEMSAVVYKDWVFTDQALPADLIKRGMAIEDPSCPHGIRLVIEDYPYAVDGLEIWDAIKTWVHEYVFLYYKSDDTLREDPELQACWKELVEVGHGDKKNEPWWPKMQTREELVEACAIIIWTASALHAAVNFGQYPYGGLILNRPTLSRRFMPEKGSAEYEELRKNPQKAYLKTITPKFQTLIDLSVIEILSRHASDEVYLGERDNPNWTSDTRALEAFKRFGNKLAQIENKLSERNNDEKLRNRCGPVQMPYTLLLPSSKEGLTFRGIPNSISI
Inhibitor
Name:
BDBM192757
Synonyms:
1,2-dimethoxy-3-(prop-2-en-1-yl)benzene (3) | Methylisoeugenol
Type:
Small organic molecule
Emp. Form.:
C11H14O2
Mol. Mass.:
178.2277
SMILES:
COc1cccc(CC=C)c1OC
Structure:
