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Target
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM235656
Substrate
n/a
Meas. Tech.
5α-Reductase Activity Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
63±1.2 nM
Citation
 Cabeza, M; Trejo, KV; González, C; García, P; Soriano, J; Heuze, Y; Bratoeff, E Steroidal 5a-reductase inhibitors using 4-androstenedione as substrate. J Enzyme Inhib Med Chem 26:712-9 (2011) [PubMed]  Article 
Target
Name:
cDNA, FLJ78895, highly similar to 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
5-alpha-Reductase (5α-Reductase)
Type:
Enzyme
Mol. Mass.:
24182.16
Organism:
Homo sapiens (Human)
Description:
EC 1.3.99.5; B7Z4L2
Residue:
212
Sequence:
MEHAAQPWRWQRRRGWRRSACWPRSPTCSAPWAARSSRGIVRRTQCTAATRCPATGSECRRGPPGWCRSCPRWPCRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM235656
Synonyms:
4-Chloro-17α-hydroxypregn-4-ene-3,20-dione (7a)
Type:
Small organic molecule
Emp. Form.:
C21H29ClO3
Mol. Mass.:
364.906
SMILES:
CC(=O)[C@@]1(O)CCC2C3CCC4=C(Cl)C(=O)CCC4(C)C3CCC12C |r,c:11|
Structure:
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