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Target
Carbonic anhydrase 6
Ligand
BDBM26187
Substrate
4-Nitrophenyl acetate (NPA)
Meas. Tech.
Esterase Activity Assay
Ki
2.10e+5±n/a nM
Citation
 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity. J Enzyme Inhib Med Chem 27:880-5 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 6
Synonyms:
CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
35371.40
Organism:
Homo sapiens (Human)
Description:
P23280
Residue:
308
Sequence:
MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
  
Inhibitor
Name:
BDBM26187
Synonyms:
α-CA inhibitor, 11 | CHEMBL14060 | US9688816, 2 | phenol
Type:
Small organic molecule
Emp. Form.:
C6H6O
Mol. Mass.:
94.1112
SMILES:
Oc1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM11326
Synonyms:
4-nitrophenyl acetate | p-Nitrophenyl Acetate
Type:
Small organic molecule
Emp. Form.:
C8H7NO4
Mol. Mass.:
181.1455
SMILES:
CC(=O)Oc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: