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Target
Carbonic anhydrase 9
Ligand
BDBM50334346
Substrate
n/a
Meas. Tech.
CO2 Hydration Assay
Ki
0.3±0.0 nM
Citation
 Pan, J; Lau, J; Mesak, F; Hundal, N; Pourghiasian, M; Liu, Z; Bénard, F; Dedhar, S; Supuran, CT; Lin, KS Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography. J Enzyme Inhib Med Chem 29:249-55 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 9
Synonyms:
CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250
Type:
Enzyme
Mol. Mass.:
49669.03
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
459
Sequence:
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
  
Inhibitor
Name:
BDBM50334346
Synonyms:
4-(3-(2-cyanophenyl)ureido)benzenesulfonamide | 4-{([(2'-Cyanophenyl)amino]carbonyl)amino}benzenesulfonamide | CA IX inhibitor, (C)3 | CHEMBL1643301
Type:
Small organic molecule
Emp. Form.:
C14H12N4O3S
Mol. Mass.:
316.335
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2C#N)cc1
Structure:
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