Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [672-711]
Ligand
BDBM50129276
Substrate
n/a
Meas. Tech.
Electrochemiluminescence (ECL)-Based Immunoassay
pH
7±n/a
IC50
66.6±n/a nM
Comments
extracted
Citation
 Pissarnitski, D; Zhao, Z Spirocyclic sulfones as gamma secretase inhibitors US Patent  US9464103 Publication Date 10/11/2016 
Target
Name:
Amyloid-beta precursor protein [672-711]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Beta-amyloid protein 40
Type:
Enzyme
Mol. Mass.:
4328.29
Organism:
Homo sapiens (Human)
Description:
aa 672-711
Residue:
40
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  
Inhibitor
Name:
BDBM50129276
Synonyms:
CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlorobenzenesulfonyl)-1,4-difluoro-6',6'-dimethyl-6,6a,8,9,10,10a-hexahydrospiro[benzo[c]isochromene-7,3'-[1,5]dioxane]
Type:
Small organic molecule
Emp. Form.:
C24H25ClF2O5S
Mol. Mass.:
498.967
SMILES:
CC1(C)OCC2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(Cl)cc2)CO1
Structure:
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