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Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM294228
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
<10.00±n/a nM
Citation
 Amberg, W; Pohlki, F; Lange, U; Wang, Y; Brewer, J; Vasudevan, A; Lao, Y; Hutchins, C; Zhao, H; Li, H Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9586942 Publication Date 3/7/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM294228
Synonyms:
N-(1-((7S,8R)-7-(azetidin-1-yl)-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl)azetidin-3-yl)-1-methyl-1H-pyrazole-4-sulfonamide | US9586942, 2
Type:
Small organic molecule
Emp. Form.:
C27H33N5O2S
Mol. Mass.:
491.648
SMILES:
Cn1cnc(c1)S(=O)(=O)NC1CN(C1)c1ccc2CC[C@@H]([C@H](Cc3ccccc3)c2c1)N1CCC1 |r|
Structure:
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