Reaction Details Report a problem with these data
Target
Laforin
Ligand
BDBM50054344
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
12160±2000 nM
Citation
 Zhang, Z; Zeng, L Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) US Patent  US9522881 Publication Date 12/20/2016 
Target
Name:
Laforin
Synonyms:
EPM2A | EPM2A_HUMAN | LAFPTPase | Lafora PTPase | Laforin
Type:
Protein
Mol. Mass.:
37158.16
Organism:
Homo sapiens (Human)
Description:
O95278
Residue:
331
Sequence:
MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL
  
Inhibitor
Name:
BDBM50054344
Synonyms:
CHEMBL3319356 | US9522881, 11a-1 L97M74 | US9844535, ID 11a-1 L97M74
Type:
Small organic molecule
Emp. Form.:
C28H20IN3O5S
Mol. Mass.:
637.445
SMILES:
Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
Structure:
Search PDB for entries with ligand similarity: