Target
ADP-ribosylhydrolase ARH3
Ligand
BDBM421493
Substrate
n/a
Meas. Tech.
ARH3 Assay
IC50
>100000±n/a nM
Citation
 McGonagle, AEJordan, AMWaszkowycz, BHutton, CPWaddell, IDHitchin, JRSmith, KMHamilton, NM PARG inhibitory compounds US Patent  US10508086 Publication Date 12/17/2019 
Target
Name:
ADP-ribosylhydrolase ARH3
Synonyms:
ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38934.22
Organism:
Homo sapiens (Human)
Description:
Q9NX46
Residue:
363
Sequence:
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
  
Inhibitor
Name:
BDBM421493
Synonyms:
US10508086, Example 83 | US10995073, Example 83
Type:
Small organic molecule
Emp. Form.:
C19H20N6O3S3
Mol. Mass.:
476.595
SMILES:
Cc1ncc(Cn2c3ccc(cc3n(-c3nnc(C)s3)c2=O)S(=O)(=O)NC2(C)CC2)s1
Structure:
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