Target
ADP-ribosylhydrolase ARH3
Ligand
BDBM421423
Substrate
n/a
Meas. Tech.
ARH3 Assay
IC50
>150000±n/a nM
Citation
 McGonagle, AEJordan, AMWaszkowycz, BHutton, CPWaddell, IDHitchin, JRSmith, KMHamilton, NM PARG inhibitory compounds US Patent  US10508086 Publication Date 12/17/2019 
Target
Name:
ADP-ribosylhydrolase ARH3
Synonyms:
ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38934.22
Organism:
Homo sapiens (Human)
Description:
Q9NX46
Residue:
363
Sequence:
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
  
Inhibitor
Name:
BDBM421423
Synonyms:
N-(1-Methylcyclopropyl)-1-[2-(2-oxooxazolidin-3-yl)acetyl]indoline-6-sulfonamide | US10508086, Example 14 | US10995073, Example 14
Type:
Small organic molecule
Emp. Form.:
C17H21N3O5S
Mol. Mass.:
379.431
SMILES:
CC1(CC1)NS(=O)(=O)c1ccc2CCN(C(=O)CN3CCOC3=O)c2c1
Structure:
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