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Target
Fibroblast growth factor receptor 2 [403-822]
Ligand
BDBM350032
Substrate
n/a
IC50
1.40±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 2 [403-822]
Synonyms:
BEK | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)(403-822) | KGFR | KSAM
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47577.40
Organism:
Homo sapiens (Human)
Description:
aa 403-822
Residue:
420
Sequence:
NTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM350032
Synonyms:
US10208024, Example 31 | US10766881, Example 31
Type:
Small organic molecule
Emp. Form.:
C24H26N8O3
Mol. Mass.:
474.515
SMILES:
COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CCNCC1
Structure:
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