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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM462978
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
Duffey, MO; England, D; Freeze, BS; Hu, Z; Langston, S; McIntyre, C; Mizutani, H; Ono, K; Xu, H Heteroaryl compounds useful as inhibitors of SUMO activating enzyme US Patent US10780090 Publication Date 9/22/2020
More Info.:
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
Inhibitor
Name:
BDBM462978
Synonyms:
US10780090, Compound I-270 | US10780090, Compound I-270a | US10780090, Compound I-270b | {(1R,2S,4R)-4-[(5-{4-[(1R)-7-chloro-3,4-dihydro-1H-isochromen-1-yl]-5-methyl-2- furoyl}pyrimidin-4-yl)amino]-2-hydroxycyclopentyl}methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C25H27ClN4O7S
Mol. Mass.:
563.022
SMILES:
Cc1oc(cc1[C@@H]1OCCc2ccc(Cl)cc12)C(=O)c1cncnc1N[C@H]1C[C@H](O)[C@@H](COS(N)(=O)=O)C1