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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM463057
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Duffey, MO; England, D; Freeze, BS; Hu, Z; Langston, S; McIntyre, C; Mizutani, H; Ono, K; Xu, H Heteroaryl compounds useful as inhibitors of SUMO activating enzyme US Patent  US10780090 Publication Date 9/22/2020 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM463057
Synonyms:
US10780090, Compound I-302 | [(1R,2R,3S,4R)-4-{[5-({5-chloro-4-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-yl]-2- thienyl}carbonyl)pyrimidin-4-yl]amino}-2,3-dihydroxycyclopentyl]methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C24H26ClN5O6S2
Mol. Mass.:
580.076
SMILES:
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ncncc2C(=O)c2cc([C@H]3NCCc4ccccc34)c(Cl)s2)[C@H](O)[C@@H]1O
Structure:
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