Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM463196
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.775±n/a nM
Citation
 Whitehead, AOrnoski, ORaghavan, SBerger, RGarfunkle, JYang, ZJi, GJiang, FFu, J Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators US Patent  US10780092 Publication Date 9/22/2020 
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Inhibitor
Name:
BDBM463196
Synonyms:
4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(4-chloro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one | US10780092, Example 50-A
Type:
Small organic molecule
Emp. Form.:
C22H21ClN8O2
Mol. Mass.:
464.908
SMILES:
CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1
Structure:
Search PDB for entries with ligand similarity: