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Target
Guanylate cyclase soluble subunit alpha-1
Ligand
BDBM463283
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
2.34±n/a nM
Citation
 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators US Patent  US10780092 Publication Date 9/22/2020 
Target
Name:
Guanylate cyclase soluble subunit alpha-1
Synonyms:
GCS-alpha-1 | GCS-alpha-3 | GCYA1_HUMAN | GUC1A3 | GUCSA3 | GUCY1A1 | GUCY1A3 | Guanylate cyclase soluble (GCS-alpha-1) | Guanylate cyclase soluble subunit alpha-3 | Solube guanylate cyclase alpha-1 (sGC alpha-1) | Solube guanylate cyclase alpha-1 (sGCalpha) | soluble guanylate cyclase alpha-1 (sGC)
Type:
Enzyme
Mol. Mass.:
77457.21
Organism:
Homo sapiens (Human)
Description:
Q02108
Residue:
690
Sequence:
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
  
Inhibitor
Name:
BDBM463283
Synonyms:
5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- [(3,3,3-trifluoro-2- hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one | US10780092, Example 133-AA | US10780092, Example 133-AB
Type:
Small organic molecule
Emp. Form.:
C25H19ClF8N8O3
Mol. Mass.:
666.91
SMILES:
CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1
Structure:
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